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A high fibre diet could slow the progression of prostate cancer
•Chemical in fibre kept prostate tumors from making the new blood
vessels they need for energy
•Without this energy, the cancer cannot grow
•May help control disease in the early stages
By Anna Hodgekiss
10 January 2013

A high fibre diet may prevent the progression of prostate cancer by
stopping tumours from growing.

Researchers have found that eating plenty of wholegrains and plant-
based foods may have the potential to control the progression of the
disease in the early stages.

They wanted to ascertain why men in Western cultures suffer from more
advanced stages of the disease, whereas their Asian counterparts do
not.

This is despite the rate of prostate cancer in both cultures being
similar.

High fibre foods such as porridge may all help slow the progression of
prostate cancer - by slowing down the blood supply to the tumours

Scientists at the University of Colorado Cancer Centre set out to find
out why, and found the answer may be a high-fibre diet

The study compared mice fed with of inositol hexaphosphate (IP6), a
major component of high-fibre diets, to a group of mice that were
not.

MRI scans were then used to study the progression of prostate cancer
in both groups.

Komal Raina, research instructor at the Skaggs School of
Pharmaceutical Sciences, said: 'The study's results were really rather
profound.'
Indeed, the researchers saw dramatically reduced tumour volumes,
primarily due to the effects IP6 had on the growth of blood vessels.
GOOD SOURCES OF FIBRE
Wholemeal, granary and softgrain varieties of bread
Jacket/new/baked potatoes in their skins

Wholegrain breakfast cereals, eg. Weetabix, bran flakes, unsweetened
muesli, Shreddies and porridge oats

Wholemeal pasta, brown rice

Beans, lentils and peas

Fresh and dried fruits – particularly if skins are eaten

Vegetables – particularly if the skins are eaten

Nuts and seeds

Wholemeal flour
..Basically, the chemical kept prostate tumors from making the new
blood vessels they needed to supply themselves with energy. Without
this energy, the cancer couldn't grow.
Without the energy, prostate cancer couldn't grow. Likewise, treatment
with IP6 slowed the rate at which prostate cancers metaboliSed
glucose.
Dr Raina added that a possible mechanism for the effect of IP6 against
metabolism include a reduction in a protein called GLUT-4, which is
instrumental in transporting glucose.
He said: 'Researchers have long been looking for genetic variations
between Asian and Western peoples that could explain the difference in
prostate cancer progression rates, but now it seems as if the
difference may not be genetic but dietary.

'Asian cultures get [more] IP6 whereas Western cultures generally do
not."
The findings were published in the journal Cancer Prevention Research.
Fibre may also play a role in preventing cancer, say researchers from
the University of California San Fransico.
Men who consumed at least 28 servings of vegetables per week had a
reduced risk of prostate cancer compared with those who ate fewer than
14 servings per week.
There is some evidence that vegetables - particularly cruciferous
vegetables like broccoli, cauliflower, cabbage, kale, Brussels sprouts
and bok choy - may be associated with a reduced risk of prostate
cancer.

----------------

Chemopreventive Efficacy of Inositol Hexaphosphate against Prostate
Tumor Growth and Progression in TRAMP Mice
Komal Raina1, Subapriya Rajamanickam1, Rana P. Singh1,3 and Rajesh
Agarwal1,2
Clinical Cancer Research 14, 3177-3184, May 15, 2008.
1 Department of Pharmaceutical Sciences, School of Pharmacy, and
2 University of Colorado Cancer Center, University of Colorado
Denver,
Denver, Colorado; and
3 Cancer Biology Laboratory, School of Life Sciences,
Jawaharlal Nehru University, New Delhi, India
Requests for reprints: Rajesh Agarwal, Department of Pharmaceutical
Sciences, School of Pharmacy, University of Colorado Denver, 4200
East
Ninth Street, Box C238, Denver, CO 80262. Phone: 303-315-1381; Fax:
303-315-6281; E-mail: Rajesh.Agar...@uchsc.edu.

Purpose: Herein, for the first time, we evaluated the in vivo
chemopreventive efficacy of inositol hexaphosphate (IP6), a major
constituent of high-fiber diets, against prostate tumor growth and
progression in the transgenic adenocarcinoma of the mouse prostate
(TRAMP) model.

Experimental Design: Beginning at 4 weeks of age, male TRAMP mice
were
fed 2% (w/v) IP6 in drinking water or only drinking water till 24
weeks of age, and then sacrificed. Prostate tissue was subjected to
histopathologic analysis and to immunohistochemical analyses for
proliferation and apoptosis.

Results: IP6 feeding did not show any adverse effect on fluid and
diet
consumption and body weight. There was a significant reduction (40%;
P
< 0.01) in lower urogenital tract weight in IP6-fed mice. IP6
inhibited prostate cancer progression at prostatic intraepithelial
neoplasia stage and strongly reduced the incidence of adenocarcinoma
(prostatic intraepithelial neoplasia/adenocarcinoma, 75:25% in the
IP6
group versus 39:61% in the control group; P < 0.05). The incidences
of
well-differentiated and poorly differentiated adenocarcinomas in the
IP6-fed group were reduced by 44% and 62%, respectively.
Immunohistochemical analysis of prostate tissue showed a 26% decrease
(P < 0.05) in proliferation cell nuclear antigen–positive cells and a
3.5-fold increase in apoptotic cells with no effect on Tag expression
by IP6.

Conclusions: These findings are both novel and highly significant in
establishing for the first time that oral IP6, without any toxicity,
suppresses prostate tumor growth and progression at the neoplastic
stage, thereby reducing the incidence of adenocarcinoma through its
antiproliferative and proapoptotic effects, and thus indicating that
IP6 could have potential chemopreventive effects against human
prostate cancer.

doi: 10.1158/1078-0432.CCR-07-5275
© 2008 American Association for Cancer Research


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