My freee bisphosphonate .. a .. gain ..

Inositol Hexaphosphate Inhibits Tumor Growth, Vascularity, and
Metabolism in TRAMP Mice: A Multiparametric Magnetic Resonance Study.
Raina K, Ravichandran K, Rajamanickam S, Huber K, Serkova NJ, Agarwal
Cancer Prev Res (Phila). 2012 Dec 4.
Pharmaceutical Science, University of Colorado Denver.

Herein, employing anatomical and dynamic contrast-enhanced (DCE)
magnetic resonance imaging (MRI), we evaluated non-invasively, the in
vivo, chemopreventive efficacy of inositol hexaphosphate (IP6), a
major constituent of high fiber diets, against prostate tumor growth
and progression in transgenic adenocarcinoma of the mouse prostate
(TRAMP) model.
Male TRAMP mice, beginning 4 weeks of age, were fed with 1, 2 or 4% (w/
v) IP6 in drinking water or only drinking water till 28 weeks of age
and monitored using MRI over the course of study.
Longitudinal assessment of prostate volumes by conventional MRI and
tumor vascularity by gadolinium-based DCE-MRI showed a profound
reduction in tumor size partly due to anti-angiogenic effects by IP6
As potential mechanisms of IP6 efficacy, decrease in the expression of
glucose transporter GLUT-4 protein together with an increase in levels
of phospho-AMP-activated kinase (AMPKTh172) were observed in prostate
tissues of mice from IP6 fed-groups, suggesting that IP6 is
interfering with the metabolic events occurring in TRAMP prostate.
Investigative metabolomics study utilizing quantitative high-
resolution 1H-NMR on prostate tissue extracts showed that IP6
significantly decreased glucose metabolism and membrane phospholipid
synthesis, in addition to causing an increase in myo-inositol levels
in the prostate.
Together, these findings show that oral IP6 supplement blocks PCa
growth and angiogenesis in TRAMP model in conjunction with metabolic
events involved in tumor sustenance.
This results in energy deprivation within the tumor, suggesting a
practical and translational potential of IP6 treatment in suppressing
growth and progression of prostate cancer in humans.


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