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Iron Accelerates Bone Loss

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  1. #1
    ironjustice Guest

    Default Iron Accelerates Bone Loss

    Iron overload accelerates bone loss in healthy postmenopausal women
    and middle-aged men: a 3-year retrospective longitudinal studyвЂ*‡
    Journal of Bone and Mineral Research
    Beom-Jun Kim M.D., Ph.D.1, Seong Hee Ahn M.D.1, Sung Jin Bae M.D.,
    Ph.D.2, Eun Hee Kim M.D.2, Seung-Hun Lee M.D., Ph.D.1, Hong-Kyu Kim
    M.D., Ph.D.2, Jae Won Choe M.D., Ph.D.2, Jung-Min Koh M.D., Ph.D.1,*,
    Ghi Su Kim M.D., Ph.D.1

    Abstract
    Despite extensive experimental and animal evidence about the
    detrimental effects of iron and its overload on bone metabolism, there
    have been no clinical studies relating iron stores to bone loss,
    especially in non-pathologic conditions.
    In the present study, we performed a large longitudinal study to
    evaluate serum ferritin concentrations in relation to annualized
    changes in bone mineral density (BMD) in healthy Koreans.
    A total of 1,729 subjects (940 postmenopausal women and 789 middle-
    aged men) aged 40 years or older who had undergone comprehensive
    routine health examinations with an average 3 years of follow-up were
    enrolled.
    BMD in proximal femur sites (i.e., the total femur, femur neck, and
    trochanter) was measured with dual-energy X-ray absorptiometry using
    the same equipment at baseline and follow-up.
    The mean age of women and men in this study was 55.8 ± 6.0 years and
    55.5 ± 7.8 years, respectively, and serum ferritin levels were
    significantly higher in men than in women (P < 0.001).
    The overall mean annualized rates of bone loss in the total femur,
    femur neck, and trochanter were -1.14%/yr, -1.17%/yr, and -1.51%/yr,
    respectively, in women and -0.27%/yr, -0.34%/yr, and -0.41%/yr,
    respectively, in men. After adjustment for potential confounders, the
    rates of bone loss in all proximal femur sites in both genders were
    significantly accelerated in a dose-response fashion across increasing
    ferritin quartile categories (P for trend = 0.043 to < 0.001).
    Consistently, compared with subjects in the lowest ferritin quartile
    category, those in the third and/or highest ferritin quartile category
    showed significantly faster bone loss in the total femur and femur
    neck in both genders (P = 0.023 to < 0.001).
    In conclusion, these data provide the first clinical evidence that
    increased total body iron stores could be an independent risk factor
    for accelerated bone loss, even in healthy populations.

    В© 2012 American Society for Bone and Mineral Research.

    DOI: 10.1002/jbmr.1692

    Who loves ya.
    Tom


    Jesus Was A Vegetarian!
    http://tinyurl.com/2r2nkh


    Man Is A Herbivore!
    http://tinyurl.com/4rq595


    DEAD PEOPLE WALKING
    http://tinyurl.com/zk9fk



  2. #2
    John H. Gohde Guest

    Default Re: Iron Accelerates Bone Loss

    On Jun 23, 12:10В*pm, ironjustice <ironjust...@cool.zzn.com> wrote:

    > Iron overload accelerates bone loss in healthy postmenopausal women
    > and middle-aged men: a 3-year retrospective longitudinal studyвЂ*‡


    Now, don't go trying those IRON brain farts on us again.

  3. #3
    Chopchinski Guest

    Default Re: Iron Accelerates Bone Loss

    <PLONK>


    On 6/23/2012 12:20 PM, John H. Gohde wrote:
    > On Jun 23, 12:10 pm, ironjustice <ironjust...@cool.zzn.com> wrote:
    >
    >> Iron overload accelerates bone loss in healthy postmenopausal women
    >> and middle-aged men: a 3-year retrospective longitudinal studyвЂ*‡

    >
    > Now, don't go trying those IRON brain farts on us again.
    >




  4. #4
    John H. Gohde Guest

    Default Re: Iron Accelerates Bone Loss

    On Jun 23, 1:37*pm, Chopchinski <.@.> wrote:
    > <PLONK>


    Keep working at it. I have faith in you Pee-Size SCIENCE brain.

  5. #5
    ironjustice Guest

    Default Re: Iron Accelerates Bone Loss

    On Jun 23, 1:20*pm, "John H. Gohde" <john.h.go...@gmail.com> wrote:
    fk ff

  6. #6
    John H. Gohde Guest

    Default Re: Iron Accelerates Bone Loss

    On Jun 23, 4:23*pm, ironjustice <ironjust...@cool.zzn.com> wrote:
    > On Jun 23, 1:20*pm, "John H. Gohde" <john.h.go...@gmail.com> wrote:
    > fk ff


    Now, don't go trying those brain farts on us again.

  7. #7
    ironjustice Guest

    Default Re: Iron Accelerates Bone Loss

    Iron overload accelerates bone loss in healthy postmenopausal women
    and middle-aged men: a 3-year retrospective longitudinal studyвЂ*‡
    Journal of Bone and Mineral Research
    Beom-Jun Kim M.D., Ph.D.1, Seong Hee Ahn M.D.1, Sung Jin Bae M.D.,
    Ph.D.2, Eun Hee Kim M.D.2, Seung-Hun Lee M.D., Ph.D.1, Hong-Kyu Kim
    M.D., Ph.D.2, Jae Won Choe M.D., Ph.D.2, Jung-Min Koh M.D., Ph.D.1,*,
    Ghi Su Kim M.D., Ph.D.1

    Abstract
    Despite extensive experimental and animal evidence about the
    detrimental effects of iron and its overload on bone metabolism,
    there
    have been no clinical studies relating iron stores to bone loss,
    especially in non-pathologic conditions.
    In the present study, we performed a large longitudinal study to
    evaluate serum ferritin concentrations in relation to annualized
    changes in bone mineral density (BMD) in healthy Koreans.
    A total of 1,729 subjects (940 postmenopausal women and 789 middle-
    aged men) aged 40 years or older who had undergone comprehensive
    routine health examinations with an average 3 years of follow-up were
    enrolled.
    BMD in proximal femur sites (i.e., the total femur, femur neck, and
    trochanter) was measured with dual-energy X-ray absorptiometry using
    the same equipment at baseline and follow-up.
    The mean age of women and men in this study was 55.8 ± 6.0 years and
    55.5 ± 7.8 years, respectively, and serum ferritin levels were
    significantly higher in men than in women (P < 0.001).
    The overall mean annualized rates of bone loss in the total femur,
    femur neck, and trochanter were -1.14%/yr, -1.17%/yr, and -1.51%/yr,
    respectively, in women and -0.27%/yr, -0.34%/yr, and -0.41%/yr,
    respectively, in men. After adjustment for potential confounders, the
    rates of bone loss in all proximal femur sites in both genders were
    significantly accelerated in a dose-response fashion across
    increasing
    ferritin quartile categories (P for trend = 0.043 to < 0.001).
    Consistently, compared with subjects in the lowest ferritin quartile
    category, those in the third and/or highest ferritin quartile
    category
    showed significantly faster bone loss in the total femur and femur
    neck in both genders (P = 0.023 to < 0.001).
    In conclusion, these data provide the first clinical evidence that
    increased total body iron stores could be an independent risk factor
    for accelerated bone loss, even in healthy populations.


    В© 2012 American Society for Bone and Mineral Research.


    DOI: 10.1002/jbmr.1692


    Who loves ya.
    Tom


    Jesus Was A Vegetarian!
    http://tinyurl.com/2r2nkh


    Man Is A Herbivore!
    http://tinyurl.com/4rq595


    DEAD PEOPLE WALKING
    http://tinyurl.com/zk9fk

  8. #8
    ironjustice Guest

    Default Re: Iron Accelerates Bone Loss

    Iron overload accelerates bone loss in healthy postmenopausal women
    and middle-aged men: a 3-year retrospective longitudinal studyвЂ*‡
    Journal of Bone and Mineral Research
    Beom-Jun Kim M.D., Ph.D.1, Seong Hee Ahn M.D.1, Sung Jin Bae M.D.,
    Ph.D.2, Eun Hee Kim M.D.2, Seung-Hun Lee M.D., Ph.D.1, Hong-Kyu Kim
    M.D., Ph.D.2, Jae Won Choe M.D., Ph.D.2, Jung-Min Koh M.D., Ph.D.1,*,
    Ghi Su Kim M.D., Ph.D.1

    Abstract
    Despite extensive experimental and animal evidence about the
    detrimental effects of iron and its overload on bone metabolism,
    there
    have been no clinical studies relating iron stores to bone loss,
    especially in non-pathologic conditions.
    In the present study, we performed a large longitudinal study to
    evaluate serum ferritin concentrations in relation to annualized
    changes in bone mineral density (BMD) in healthy Koreans.
    A total of 1,729 subjects (940 postmenopausal women and 789 middle-
    aged men) aged 40 years or older who had undergone comprehensive
    routine health examinations with an average 3 years of follow-up were
    enrolled.
    BMD in proximal femur sites (i.e., the total femur, femur neck, and
    trochanter) was measured with dual-energy X-ray absorptiometry using
    the same equipment at baseline and follow-up.
    The mean age of women and men in this study was 55.8 ± 6.0 years and
    55.5 ± 7.8 years, respectively, and serum ferritin levels were
    significantly higher in men than in women (P < 0.001).
    The overall mean annualized rates of bone loss in the total femur,
    femur neck, and trochanter were -1.14%/yr, -1.17%/yr, and -1.51%/yr,
    respectively, in women and -0.27%/yr, -0.34%/yr, and -0.41%/yr,
    respectively, in men. After adjustment for potential confounders, the
    rates of bone loss in all proximal femur sites in both genders were
    significantly accelerated in a dose-response fashion across
    increasing
    ferritin quartile categories (P for trend = 0.043 to < 0.001).
    Consistently, compared with subjects in the lowest ferritin quartile
    category, those in the third and/or highest ferritin quartile
    category
    showed significantly faster bone loss in the total femur and femur
    neck in both genders (P = 0.023 to < 0.001).
    In conclusion, these data provide the first clinical evidence that
    increased total body iron stores could be an independent risk factor
    for accelerated bone loss, even in healthy populations.


    В© 2012 American Society for Bone and Mineral Research.


    DOI: 10.1002/jbmr.1692


    Who loves ya.
    Tom


    Jesus Was A Vegetarian!
    http://tinyurl.com/2r2nkh


    Man Is A Herbivore!
    http://tinyurl.com/4rq595


    DEAD PEOPLE WALKING
    http://tinyurl.com/zk9fk


  9. #9
    Donna G Guest

    Default Re: TOMMY THE SPAMMER!




    Iron overload has affected little Tommy's brain and he posts nonsense
    and has had run ins with the police and harmed people with his false
    advice!

    SPAMMER!!!

    ..
    ..
    Donna G.
    ..

    1) Rejoice always, Pray continually, Give thanks in all circumstances,
    For this is God's will for you in Christ Jesus. ( I Thessalonians
    5:16-18 NIV )

    2) ANGELS EXIST, but some times, since they don't all have wings, we
    call them FRIENDS......

    3) Just because you're in pain, doesn't mean you have to be one!


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