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Gut Bacteria Link To Rheumatoid Arthritis

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  1. #1
    Donna G Guest

    Default Gut Bacteria Link To Rheumatoid Arthritis




    Gut Bacteria Link to Rheumatoid Arthritis

    Gut Bacteria Link to Rheumatoid Arthritis

    Bacteria in the digestive system might predict who may develop RA, and
    help scientists develop novel therapies for the disease.
    By Susan Bernstein

    For years, scientists have wondered if there was a connection between
    the type of bacteria in our bodies, particularly our guts, and the
    development of RA. Could tiny micro-organisms predict who is most
    susceptible to developing RA and who might be more resistant to the
    disease?

    A recent study shows some strong connections between the type of
    bacteria in our guts and certain genes that may predict RA development

    A team of researchers from the Mayo Clinic in Rochester, Minn., and the
    University of Illinois at Urbana published a study in the peer-reviewed
    journal Public Library of Science

    One in April showing that the types of bacteria lurking in the guts of
    mice may predict which animals are more susceptible to developing RA and
    collagen-induced arthritis (CIA), and which mice may be more resistant
    to the disease.

    In addition, another set of scientists at the University of Illinois at
    Urbana have just completed a study of humans to examine how consuming
    different types and amounts of dietary fiber could change their gut
    bacteria, shifting the mix toward more bacteria with potentially
    anti-inflammatory properties. Their study will be published in the
    Journal of Nutrition this summer.

    For years, Veena Tareja, PhD, worked with RA patients at the Mayo Clinic
    and listened to their observations about the connection between diet and
    inflammation. "They would say, 'I eat this and my arthritis gets worse.'
    I always had the feeling that the gut had something to do with
    arthritis, because it takes most of the body's abuse," says Tareja, the
    institution's lead researcher on the new study.

    Genes and Bugs

    Tareja and her colleagues knew that there were already strong
    correlations between mice that carry genes with particular genetic
    variations called alleles and the susceptibility to develop – or
    resist developing – RA.

    Mice with the gene HLA-DRB1*0401 are more susceptible to developing RA
    and CIA, while mice with the gene HLA-DRB1*0402 are more resistant.

    In addition, they knew the 0401 allele's presence in people with
    arthritis was also strongly correlated to gender; three females to one
    male carrying that gene develop arthritis.

    They suspected that the different genes must trigger different reactions
    in the guts of the mice that tipped the susceptibility scale one way or
    the other.

    Several recent studies, including a paper published in Arthritis &
    Rheumatism in 2010 by rheumatologist Jose Scher, MD, and his colleagues
    at the Arthritis Clinic of New York University Hospital for Joint
    Diseases, also established a connection between the presence of certain
    bacteria in the body, namely inflamed gums, and RA.*

    Dr. Scher urges that finding particular bacteria in the gums of people
    with RA does not necessarily mean those bugs trigger RA, but is merely
    one step on the road to understanding possible connections. "This
    remains an association and causality will be difficult to prove," he
    says.

    Taneja and her colleagues felt that there might be some connection to
    the gut bacteria found in mice with the particular HLA genes. "We
    thought, 'There's got to be something this gene is doing. Our genes
    affect what these bugs are doing. The genes and the bugs are related
    somehow,'" she says.*

    She also says that the gut microbiome, or the type of bacteria that are
    in a person's digestive system, are affected by various factors,
    including diet, and more likely, our genes. "We all walk around with
    millions of bugs inside us, but the balance of bugs makes the
    difference, along with genes. Until now, nobody took it seriously, but
    now with new technology, we can see these bugs."*

    Scientists once had to examine bacteria in a
    Petri dish, says Dr. Scher, but now, they can sequence the bacteria's
    DNA and analyze the bugs more accurately.

    ..
    ..
    Donna G.
    ..

    1) Rejoice always, Pray continually, Give thanks in all circumstances,
    For this is God's will for you in Christ Jesus. ( I Thessalonians
    5:16-18 NIV )

    2) ANGELS EXIST, but some times, since they don't all have wings, we
    call them FRIENDS......

    3) Just because you're in pain, doesn't mean you have to be one!


  2. #2
    [email protected] Guest

    Default Re: Gut Bacteria Link To Rheumatoid Arthritis

    Also see Professor Alan Ebringer on Diet and Ankylosing Spondylitis - YouTube
    and various papers and presentations connected with RA.

    Peter B



    On Thursday, July 26, 2012 5:00:09 PM UTC+1, Donna G wrote:
    > Gut Bacteria Link to Rheumatoid Arthritis
    >
    >
    >
    > Gut Bacteria Link to Rheumatoid Arthritis
    >
    >
    >
    > Bacteria in the digestive system might predict who may develop RA, and
    >
    > help scientists develop novel therapies for the disease.
    >
    > By Susan Bernstein
    >
    >
    >
    > For years, scientists have wondered if there was a connection between
    >
    > the type of bacteria in our bodies, particularly our guts, and the
    >
    > development of RA. Could tiny micro-organisms predict who is most
    >
    > susceptible to developing RA and who might be more resistant to the
    >
    > disease?
    >
    >
    >
    > A recent study shows some strong connections between the type of
    >
    > bacteria in our guts and certain genes that may predict RA development
    >
    >
    >
    > A team of researchers from the Mayo Clinic in Rochester, Minn., and the
    >
    > University of Illinois at Urbana published a study in the peer-reviewed
    >
    > journal Public Library of Science
    >
    >
    >
    > One in April showing that the types of bacteria lurking in the guts of
    >
    > mice may predict which animals are more susceptible to developing RA and
    >
    > collagen-induced arthritis (CIA), and which mice may be more resistant
    >
    > to the disease.
    >
    >
    >
    > In addition, another set of scientists at the University of Illinois at
    >
    > Urbana have just completed a study of humans to examine how consuming
    >
    > different types and amounts of dietary fiber could change their gut
    >
    > bacteria, shifting the mix toward more bacteria with potentially
    >
    > anti-inflammatory properties. Their study will be published in the
    >
    > Journal of Nutrition this summer.
    >
    >
    >
    > For years, Veena Tareja, PhD, worked with RA patients at the Mayo Clinic
    >
    > and listened to their observations about the connection between diet and
    >
    > inflammation. "They would say, 'I eat this and my arthritis gets worse.'
    >
    > I always had the feeling that the gut had something to do with
    >
    > arthritis, because it takes most of the body's abuse," says Tareja, the
    >
    > institution's lead researcher on the new study.
    >
    >
    >
    > Genes and Bugs
    >
    >
    >
    > Tareja and her colleagues knew that there were already strong
    >
    > correlations between mice that carry genes with particular genetic
    >
    > variations called alleles and the susceptibility to develop – or
    >
    > resist developing – RA.
    >
    >
    >
    > Mice with the gene HLA-DRB1*0401 are more susceptible to developing RA
    >
    > and CIA, while mice with the gene HLA-DRB1*0402 are more resistant.
    >
    >
    >
    > In addition, they knew the 0401 allele's presence in people with
    >
    > arthritis was also strongly correlated to gender; three females to one
    >
    > male carrying that gene develop arthritis.
    >
    >
    >
    > They suspected that the different genes must trigger different reactions
    >
    > in the guts of the mice that tipped the susceptibility scale one way or
    >
    > the other.
    >
    >
    >
    > Several recent studies, including a paper published in Arthritis &
    >
    > Rheumatism in 2010 by rheumatologist Jose Scher, MD, and his colleagues
    >
    > at the Arthritis Clinic of New York University Hospital for Joint
    >
    > Diseases, also established a connection between the presence of certain
    >
    > bacteria in the body, namely inflamed gums, and RA.*
    >
    >
    >
    > Dr. Scher urges that finding particular bacteria in the gums of people
    >
    > with RA does not necessarily mean those bugs trigger RA, but is merely
    >
    > one step on the road to understanding possible connections. "This
    >
    > remains an association and causality will be difficult to prove," he
    >
    > says.
    >
    >
    >
    > Taneja and her colleagues felt that there might be some connection to
    >
    > the gut bacteria found in mice with the particular HLA genes. "We
    >
    > thought, 'There's got to be something this gene is doing. Our genes
    >
    > affect what these bugs are doing. The genes and the bugs are related
    >
    > somehow,'" she says.*
    >
    >
    >
    > She also says that the gut microbiome, or the type of bacteria that are
    >
    > in a person's digestive system, are affected by various factors,
    >
    > including diet, and more likely, our genes. "We all walk around with
    >
    > millions of bugs inside us, but the balance of bugs makes the
    >
    > difference, along with genes. Until now, nobody took it seriously, but
    >
    > now with new technology, we can see these bugs."*
    >
    >
    >
    > Scientists once had to examine bacteria in a
    >
    > Petri dish, says Dr. Scher, but now, they can sequence the bacteria's
    >
    > DNA and analyze the bugs more accurately.
    >
    >
    >
    > .
    >
    > .
    >
    > Donna G.
    >
    > .
    >
    >
    >
    > 1) Rejoice always, Pray continually, Give thanks in all circumstances,
    >
    > For this is God's will for you in Christ Jesus. ( I Thessalonians
    >
    > 5:16-18 NIV )
    >
    >
    >
    > 2) ANGELS EXIST, but some times, since they don't all have wings, we
    >
    > call them FRIENDS......
    >
    >
    >
    > 3) Just because you're in pain, doesn't mean you have to be one!


  3. #3
    Donna G Guest

    Default Re: Gut Bacteria Link To Rheumatoid Arthritis - Peter





    Hi Peter!

    Good to see you stopping by.

    Unfortunately, I can't access UTube or a number of other sites with
    webtv.

    Wish I could so I could check out what they had to say.

    I found this article quite interesting.

    ..
    ..
    Donna G.
    ..

    1) Rejoice always, Pray continually, Give thanks in all circumstances,
    For this is God's will for you in Christ Jesus. ( I Thessalonians
    5:16-18 NIV )

    2) ANGELS EXIST, but some times, since they don't all have wings, we
    call them FRIENDS......

    3) Just because you're in pain, doesn't mean you have to be one!


  4. #4
    Eric Guest

    Default Re: Gut Bacteria Link To Rheumatoid Arthritis

    Imagine that! Disease related to dietary intake! Miracles will never cease!
    Who'd a thunk it?


    wrote in message
    news:[email protected]..
    Also see Professor Alan Ebringer on Diet and Ankylosing Spondylitis -
    YouTube
    and various papers and presentations connected with RA.
    Peter B



    On Thursday, July 26, 2012 5:00:09 PM UTC+1, Donna G wrote:
    > Gut Bacteria Link to Rheumatoid Arthritis


    > Gut Bacteria Link to Rheumatoid Arthritis
    > Bacteria in the digestive system might predict who may develop RA, and


    > help scientists develop novel therapies for the disease.


    > By Susan Bernstein


    > For years, scientists have wondered if there was a connection between
    >
    > the type of bacteria in our bodies, particularly our guts, and the
    >
    > development of RA. Could tiny micro-organisms predict who is most
    >
    > susceptible to developing RA and who might be more resistant to the
    >
    > disease?
    >
    >
    >
    > A recent study shows some strong connections between the type of
    >
    > bacteria in our guts and certain genes that may predict RA development
    >
    >
    >
    > A team of researchers from the Mayo Clinic in Rochester, Minn., and the
    >
    > University of Illinois at Urbana published a study in the peer-reviewed
    >
    > journal Public Library of Science
    >
    >
    >
    > One in April showing that the types of bacteria lurking in the guts of
    > mice may predict which animals are more susceptible to developing RA and
    > collagen-induced arthritis (CIA), and which mice may be more resistant
    > to the disease.
    > In addition, another set of scientists at the University of Illinois at
    > Urbana have just completed a study of humans to examine how consuming
    > different types and amounts of dietary fiber could change their gut
    > bacteria, shifting the mix toward more bacteria with potentially
    > anti-inflammatory properties. Their study will be published in the
    > Journal of Nutrition this summer.
    >
    >
    >
    > For years, Veena Tareja, PhD, worked with RA patients at the Mayo Clinic
    >
    > and listened to their observations about the connection between diet and
    >
    > inflammation. "They would say, 'I eat this and my arthritis gets worse.'
    >
    > I always had the feeling that the gut had something to do with
    >
    > arthritis, because it takes most of the body's abuse," says Tareja, the
    >
    > institution's lead researcher on the new study.
    > Genes and Bugs
    > Tareja and her colleagues knew that there were already strong
    >
    > correlations between mice that carry genes with particular genetic
    >
    > variations called alleles and the susceptibility to develop – or
    >
    > resist developing – RA.
    > Mice with the gene HLA-DRB1*0401 are more susceptible to developing RA
    > and CIA, while mice with the gene HLA-DRB1*0402 are more resistant.
    > In addition, they knew the 0401 allele's presence in people with
    > arthritis was also strongly correlated to gender; three females to one
    > male carrying that gene develop arthritis.
    > They suspected that the different genes must trigger different reactions
    > in the guts of the mice that tipped the susceptibility scale one way or
    > the other.
    > Several recent studies, including a paper published in Arthritis &
    >
    > Rheumatism in 2010 by rheumatologist Jose Scher, MD, and his colleagues
    >
    > at the Arthritis Clinic of New York University Hospital for Joint
    >
    > Diseases, also established a connection between the presence of certain
    >
    > bacteria in the body, namely inflamed gums, and RA.
    > Dr. Scher urges that finding particular bacteria in the gums of people
    >
    > with RA does not necessarily mean those bugs trigger RA, but is merely
    >
    > one step on the road to understanding possible connections. "This
    >
    > remains an association and causality will be difficult to prove," he
    >
    > says.
    >
    >
    >
    > Taneja and her colleagues felt that there might be some connection to
    >
    > the gut bacteria found in mice with the particular HLA genes. "We
    >
    > thought, 'There's got to be something this gene is doing. Our genes
    >
    > affect what these bugs are doing. The genes and the bugs are related
    >
    > somehow,'" she says.
    >
    >
    >
    > She also says that the gut microbiome, or the type of bacteria that are
    >
    > in a person's digestive system, are affected by various factors,
    >
    > including diet, and more likely, our genes. "We all walk around with
    >
    > millions of bugs inside us, but the balance of bugs makes the
    >
    > difference, along with genes. Until now, nobody took it seriously, but
    >
    > now with new technology, we can see these bugs."
    >
    >
    >
    > Scientists once had to examine bacteria in a
    >
    > Petri dish, says Dr. Scher, but now, they can sequence the bacteria's
    >
    > DNA and analyze the bugs more accurately.
    > Donna G.
    > 1) Rejoice always, Pray continually, Give thanks in all circumstances,
    >
    > For this is God's will for you in Christ Jesus. ( I Thessalonians
    >
    > 5:16-18 NIV )
    > 2) ANGELS EXIST, but some times, since they don't all have wings, we
    >
    > call them FRIENDS......
    >
    >
    >
    > 3) Just because you're in pain, doesn't mean you have to be one!



  5. #5
    Trimble Bracegirdle Guest

    Default Re: Gut Bacteria Link To Rheumatoid Arthritis

    Thanks Donna G for Info .
    Presumably this is specifically RA no OA connection?

    (\__/)
    (='.'=) This is Bunny. Copy and paste Bunny into your
    (")_(") signature to help him gain world domination.

  6. #6
    Donna G Guest

    Default Re: Gut Bacteria Link To Rheumatoid Arthritis - TB




    Yes, this was more specific to rheumatoid arthritis, but does make me
    wonder if perhaps it could be also effect forms of OA, especially the
    more aggressive forms that can sort of mimic RA.

    ..
    ..
    Donna G.
    ..

    1) Rejoice always, Pray continually, Give thanks in all circumstances,
    For this is God's will for you in Christ Jesus. ( I Thessalonians
    5:16-18 NIV )

    2) ANGELS EXIST, but some times, since they don't all have wings, we
    call them FRIENDS......

    3) Just because you're in pain, doesn't mean you have to be one!


  7. #7
    Donna G Guest

    Default Re: Gut Bacteria Link To Rheumatoid Arthritis - TB



    ..
    ..
    Donna G.
    ..

    1) Rejoice always, Pray continually, Give thanks in all circumstances,
    For this is God's will for you in Christ Jesus. ( I Thessalonians
    5:16-18 NIV )

    2) ANGELS EXIST, but some times, since they don't all have wings, we
    call them FRIENDS......

    3) Just because you're in pain, doesn't mean you have to be one!


  8. #8
    Harvey Guest

    Default Re: Gut Bacteria Link To Rheumatoid Arthritis - TB



    "Donna G" wrote in message
    news:[email protected]..
    ..
    ..
    Donna G.
    ..
    awhhhh,,,, I THINK THIS is the answer to what we have been wanting for years
    and years. I know it will kill the profit of many a drug supplier and
    will not be feed by the press but since I had it proven to me in my
    fight with my lungs,,,, I know RA can be handled by drugs going through our
    gut....... This could be wonderful for sooooo many people that have more
    than RA.....
    I know they would solve our problem but I did not think this would be
    the answer. But now I do.
    We will have to watch the wheels turn and things take place but It is
    going to Happpen. Ok,,, we will see.

    Harv


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