Dumbed right down.
This would be a 'human model of iron overload'.

"Cirrhosis , Carcinoma , Diabetes , Heart Failure , Osteoporosis ,

Haemochromatosis: The bone and the joint
Pascal Guggenbuhl MD, PhDa, Professor of Rheumatology,
Pierre Brissot MD, PhDc, Professor of Hepatology,
Olivier Lorйal MD, PhDa, Research Director
Best Practice & Research Clinical Rheumatology
Volume 25, Issue 5, October 2011, Pages 649-664
Miscellaneous Non-Inflammatory Musculoskeletal Conditions
a INSERM UMR 991, F-35000 Rennes, France
b Service de Rhumatologie, Hфpital Sud, CHU F- 35000 Rennes, France
c Universitй de Rennes 1, IFR 140, F- 35000 Rennes, France
d Service des Maladies du Foie, INSERM UMR 991, F-35000 Rennes,
e Centre de Rйfйrence des Surcharges en Fer rares d–Origine Gйnйtique,
Hфpital Pontchaillou, F-35000 Rennes, France
Available online 3 December 2011.

Genetic haemochromatosis is a hereditary disease characterised by
tissue iron overload.
In Caucasians it is most often due to homozygous C282Y HFE gene
mutation, but other genes may be involved.
Without treatment by venesections, patients can develop life-
threatening visceral damage such as liver cirrhosis and carcinoma,
diabetes or heart failure.
This treatment has been remarkably successful in preventing these
complications, but patients survive with other symptoms of the disease
susceptible to impair, sometimes seriously, their quality of life.
This is the case of arthropathy and osteoporosis complicating
In this chapter, focus has been placed on the rheumatological
complications of genetic haemochromatosis.

Keywords: Haemochromatosis; Iron; HFE gene; Hepcidin; Osteoporosis;
Chondrocalcinosis; Osteoarthritis; CPPD; Osteoporosis; Fracture

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