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Any Word on The COX2 Type Anti-Inflamatery Drugs ?

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  1. #1
    Trimble Bracegirdle Guest

    Default Any Word on The COX2 Type Anti-Inflamatery Drugs ?

    Here in the UK these were almost completely withdrawn 2 + years back
    because of the Long Term side effects possibilities.
    And comprehensive research was announced to decide
    how the COX2 types might be used.

    Any News / progress on this?

    I know a number of people who found Celebrex (COX2 type)
    more effective than the COX1 types.

    There is hardly anything in the UK now that's prescribed for regular
    long term use other than DICLOFENAC . (has many other names)
    Ibuprofen, with Paracetamol prescribed for general pain relief.
    These are the names used in the UK.
    @@@mouse@@@

  2. #2
    Smokie Darling (Annie) Guest

    Default Re: Any Word on The COX2 Type Anti-Inflamatery Drugs ?

    On Mar 16, 11:36*am, "Trimble Bracegirdle" <no-s...@never.spam> wrote:
    > Here in the UK these were almost completely withdrawn 2 + years back
    > because of the Long Term side effects possibilities.
    > And comprehensive research was announced to decide
    > how the COX2 types might be used.
    >
    > Any News / progress on this?


    I have a neighbor taking Celebrex, long term, she never stopped taking
    it. The black box warning was put in place, and her doctor monitors
    her blood work every month. I think she takes half a pill in the
    morning and half at night. She loves the stuff.

    My own physicians have said that the "problems" reported were for
    people being given 3 or 4 times the maximum dosage recommended by the
    manufacturer (i.e., they weren't supposed to exceed 200mg a day, and
    they were taking 600 to 800mg).

    > I know a number of people who found Celebrex (COX2 type)
    > more effective than the COX1 types.
    >
    > There is hardly anything in the UK now that's prescribed for regular
    > long term use other than DICLOFENAC


    Voltaren (I know no one personally, who takes this)

    .. (has many other names)
    > Ibuprofen,


    Motrin or Advil (or ibuprofen <smile>)

    with Paracetamol prescribed for general pain relief.

    Tylenol or Acetominophen (I'm allergic to this crap)

    Naproxen is pretty popular here. I've been on Ibuprofen for years
    (since 1996 at least). I don't think it's working until I miss a dose
    (as it's a blood level type drug), then I realize just how well it
    *had* been working.

  3. #3
    Navy Guest

    Default Re: Any Word on The COX2 Type Anti-Inflamatery Drugs ?

    On 3/16/2011 1:36 PM, Trimble Bracegirdle wrote:
    > Here in the UK these were almost completely withdrawn 2 + years back
    > because of the Long Term side effects possibilities.
    > And comprehensive research was announced to decide how the COX2 types
    > might be used.
    >
    > Any News / progress on this?
    >
    > I know a number of people who found Celebrex (COX2 type) more effective
    > than the COX1 types.
    >
    > There is hardly anything in the UK now that's prescribed for regular
    > long term use other than DICLOFENAC . (has many other names)
    > Ibuprofen, with Paracetamol prescribed for general pain relief.
    > These are the names used in the UK.
    > @@@mouse@@@


    My rheumy prescribed Celebrex for me and it did absolutely nothing for
    me. So she put me on Arthrotec which is voltaren with something to calm
    the stomach. It really works on me and I haven't had any problems with
    my stomach. She also checks my blood on a regular basis. Welcome to
    the group. We are mostly on Facebook, now, but some of us check here.

    --
    Navy remove the fish

  4. #4
    Leslie & The Furbabies in MO. Guest

    Default Re: Any Word on The COX2 Type Anti-Inflamatery Drugs ?

    I took Celebrex with Ultracet for about 4-5 months roughly 15 years ago.
    Between the Celebrex and acetomeniphen they damaged my kidneys- renal
    papillary necrosis. I have been considered to be in kidney failure even
    tho my creatinine clearance came back up to slightly below normal. The
    diagnosis requires an IVP scan and 24 hr. urine collection for testing.
    The blood creatinine reading doesn't show the kidney damage.

    And the Celebrex didn't help my OA and RA at all.

    Leslie

    "Trimble Bracegirdle" wrote in message
    news:ilqseq$c45$[email protected]..

    Here in the UK these were almost completely withdrawn 2 + years back
    because of the Long Term side effects possibilities.
    And comprehensive research was announced to decide
    how the COX2 types might be used.

    Any News / progress on this?

    I know a number of people who found Celebrex (COX2 type)
    more effective than the COX1 types.

    There is hardly anything in the UK now that's prescribed for regular
    long term use other than DICLOFENAC . (has many other names)
    Ibuprofen, with Paracetamol prescribed for general pain relief.
    These are the names used in the UK.
    @@@mouse@@@


  5. #5
    Peter Guest

    Default Re: Any Word on The COX2 Type Anti-Inflamatery Drugs ?

    On Mar 17, 7:40*pm, "Leslie & The Furbabies in MO."
    <quilteac...@yahoo.com> wrote:
    > I took Celebrex with Ultracet for about 4-5 months roughly 15 years ago.
    > Between the Celebrex and acetomeniphen they damaged my kidneys- renal
    > papillary necrosis. * I have been considered to be in kidney failure even
    > tho my creatinine clearance came back up to slightly below normal. * The
    > diagnosis requires an IVP scan and 24 hr. urine collection for testing.
    > The blood creatinine reading doesn't show the kidney damage.
    >
    > And the Celebrex didn't help my OA and RA at all.
    >
    > Leslie
    >
    > "Trimble Bracegirdle" *wrote in message
    >
    > news:ilqseq$c45$[email protected]..
    >
    > Here in the UK these were almost completely withdrawn 2 + years back
    > because of the Long Term side effects possibilities.
    > And comprehensive research was announced to decide
    > how the COX2 types might be used.
    >
    > Any News / progress on this?
    >
    > I know a number of people who found Celebrex (COX2 type)
    > more effective than the COX1 types.
    >
    > There is hardly anything in the UK now that's prescribed for regular
    > long term use other than DICLOFENAC . (has many other names)
    > Ibuprofen, with Paracetamol prescribed for general pain relief.
    > These are the names used in the UK.
    > @@@mouse@@@


    The real reason why they were withdrawn in the UK was financial. They
    were more expensive than non COX2 NSAIDs. COX2s can be obtained on
    prescription in the UK, presumably at the discretion of the GP/
    rheumatologist. The side effects although different, do not actually
    seem to be worse than the stomach boring intestinal upsetting non
    COX2s.

    Peter

  6. #6
    Donna G. Guest

    Default Re: Any Word on The COX2 Type Anti-Inflamatery Drugs ?




    Didn't they pull many of the cox2's off the market because of increased
    risk of heart attacks and such?

    Seems to me I remember one of the long time members (Dan mayber?) who
    did have a heart attack due to being on the cox2's.

    They do still make one or two of them if I'm not mistaken.

    ..
    ..
    Donna
    ..
    ..
    ..
    ..
    1) Just because you're in pain, doesn't mean you have to be one!
    ..
    2) ANGELS EXIST, but some times, since they don't all have wings, we
    call them FRIENDS......



  7. #7
    Leslie & The Furbabies in MO. Guest

    Default Donna! Hi!


    Donna, welcome back! How are you doing? Is your new knee all you hoped
    it would be? I missed you and your wise and helpful and cheerful posts.

    Leslie

    "Donna G." wrote in message
    news:[email protected]..




    Didn't they pull many of the cox2's off the market because of increased
    risk of heart attacks and such?

    Seems to me I remember one of the long time members (Dan mayber?) who
    did have a heart attack due to being on the cox2's.

    They do still make one or two of them if I'm not mistaken.

    ..
    ..
    Donna
    ..
    ..
    ..
    ..
    1) Just because you're in pain, doesn't mean you have to be one!
    ..
    2) ANGELS EXIST, but some times, since they don't all have wings, we
    call them FRIENDS......


  8. #8
    Donna G. Guest

    Default Re: Donna! Hi!



    Hi Leslie,


    I am doing pretty well!

    The new knee is doing pretty good. Surgery itself went well and at my 1
    month check with the ortho, he said he was very pleased with how it
    looked both on x-ray and how the scar and such looked. He also seemed
    pleased that I can bend it to 120┬░ and am walking pretty well on it
    too!

    Only problem I have had with it, is that it clicks a lot when I walk,
    and the ortho said that isn't uncommon and should get better and better.

    Also have had a rough time with terrible muscle spasms in the upper
    thigh since the surgery. Pain meds and muscle relaxers don't seem to be
    doing a whole lot to help either.

    Physical therapist looked at it the other day and couldn't believe how
    terribly spasmed up and full of knots it was. She worked on it for
    almost an hour trying to release the knots. Said it is something called
    an IT Band? Need to strengthen and stretch it more. She did some type
    of taping on it, and believe it or not, the taping has helped
    tremendously! Wow, who would have ever thought!!! I'm glad that I had
    her look at it.

    One more week of therapy, then on to the second replacement! Hopefully
    by June these will be all healed and good to go!

    How are YOU doing / feeling these days? How are the dogs doing?

    ..
    ..
    Donna
    ..
    ..
    ..
    ..
    1) Just because you're in pain, doesn't mean you have to be one!
    ..
    2) ANGELS EXIST, but some times, since they don't all have wings, we
    call them FRIENDS......



  9. #9
    Nann Bell Guest

    Default Re: Any Word on The COX2 Type Anti-Inflamatery Drugs ?

    No other anti-inflammatory? According to my GI, Diclofenac is the *worst* of
    the NSAIDs for GI side effects. There are a number of other NSAIDs that are
    not among the COX2s. i don't know anything about the further research
    though. Been too busy with other ills.

    ---
    Nann
    remove the Gator cheer to email me
    You can see a lot by just looking - Yogi Berra

    On Wed, 16 Mar 2011 13:36:20 -0400, Trimble Bracegirdle wrote
    (in message <ilqseq$c45$[email protected]>):

    > Here in the UK these were almost completely withdrawn 2 + years back
    > because of the Long Term side effects possibilities.
    > And comprehensive research was announced to decide
    > how the COX2 types might be used.
    >
    > Any News / progress on this?
    >
    > I know a number of people who found Celebrex (COX2 type)
    > more effective than the COX1 types.
    >
    > There is hardly anything in the UK now that's prescribed for regular
    > long term use other than DICLOFENAC . (has many other names)
    > Ibuprofen, with Paracetamol prescribed for general pain relief.
    > These are the names used in the UK.
    > @@@mouse@@@




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